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SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.2
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 2 Soft Gels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%
Saturated Fat
0 g
0%
Trans Fat
0 g
†
Vitamin D3 (cholecalciferol)
25 mcg (1000 IU)
125%
Total Omega-3s♦
1280 mg
†
EPA (Eicosapentaenoic Acid)
650 mg
†
DHA (Docosahexaenoic Acid)
450 mg
†
Top Medical Research Studies
1
Vitamin D3 shows no benefit
Effect of Vitamin D Supplementation on Tibial Cartilage Volume and Knee Pain Among Patients With Symptomatic Knee Osteoarthritis: A Randomized Clinical Trial.
Study directly explores vitamin D3.
We conducted a thorough investigation into the effects of vitamin D3 supplementation on knee pain and cartilage volume in people suffering from knee osteoarthritis, particularly those with low vitamin D levels. This study took place in Tasmania and Victoria, Australia, and was designed as a multicenter, randomized, double-blind, placebo-controlled clinical trial.
Over a span of two years, we divided participants into two groups: one received a monthly dose of oral vitamin D3 (50,000 IU), while the other group received a placebo. Our main focus was to evaluate any changes in tibial cartilage volume, measured through MRI, as well as the participants' knee pain levels as indicated by the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score.
The results showed that, compared to the placebo group, those who received vitamin D3 experienced no significant differences in either tibial cartilage volume or reported knee pain over the two years. This indicates that vitamin D3 supplementation does not provide meaningful benefits for reducing tibial cartilage loss or improving knee pain in patients with symptomatic knee osteoarthritis.
Over a span of two years, we divided participants into two groups: one received a monthly dose of oral vitamin D3 (50,000 IU), while the other group received a placebo. Our main focus was to evaluate any changes in tibial cartilage volume, measured through MRI, as well as the participants' knee pain levels as indicated by the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score.
The results showed that, compared to the placebo group, those who received vitamin D3 experienced no significant differences in either tibial cartilage volume or reported knee pain over the two years. This indicates that vitamin D3 supplementation does not provide meaningful benefits for reducing tibial cartilage loss or improving knee pain in patients with symptomatic knee osteoarthritis.
Read More
1
Vitamin D3 ineffective for knee pain
Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial.
Study directly focuses on vitamin D3
We conducted a thorough investigation into whether vitamin D3 supplementation could alleviate knee pain in individuals with osteoarthritis. Our study involved 146 participants, all experiencing symptomatic knee osteoarthritis. They were either given a placebo or oral doses of vitamin D3, specifically aimed at achieving serum levels greater than 36 ng/mL over two years.
The main focus was on evaluating changes in knee pain and cartilage loss, utilizing the Western Ontario and McMaster Universities (WOMAC) pain scale for symptoms and magnetic resonance imaging for cartilage assessment. Unfortunately, our findings revealed that vitamin D supplementation did not lead to any significant reduction in knee pain or cartilage loss when compared to the placebo.
While we were hopeful that vitamin D3 might provide some relief, the results clearly indicated that this approach did not yield the desired effects in patients suffering from knee osteoarthritis. This outcome is crucial as it helps to shape future treatment approaches for this common condition.
The main focus was on evaluating changes in knee pain and cartilage loss, utilizing the Western Ontario and McMaster Universities (WOMAC) pain scale for symptoms and magnetic resonance imaging for cartilage assessment. Unfortunately, our findings revealed that vitamin D supplementation did not lead to any significant reduction in knee pain or cartilage loss when compared to the placebo.
While we were hopeful that vitamin D3 might provide some relief, the results clearly indicated that this approach did not yield the desired effects in patients suffering from knee osteoarthritis. This outcome is crucial as it helps to shape future treatment approaches for this common condition.
Read More
9
Vitamin D3 reduces knee OA pain
The influence of vitamin D supplementation on the expression of mediators of inflammation in knee osteoarthritis.
High relevance to knee pain treatment
We aimed to understand the therapeutic impact of vitamin D3 on knee pain associated with osteoarthritis (OA). In a 3-month open-label clinical trial, we observed 80 patients with knee OA who took an oral supplement of vitamin D3 at a dosage of 4000 IU per day.
Over the course of the study, we measured the participants' pain levels and functionality using WOMAC subscores and Visual Analog Scale (VAS) assessments. Excitingly, we found that the average pain intensity decreased significantly after treatment. In fact, about 87% of the participants showed a notable positive response to the vitamin D3 supplementation.
Alongside improvements in pain, we also noted changes in certain inflammation markers in the blood. There was a significant decrease in pro-inflammatory cytokines like TNF-α and IL-17, while levels of IL-33 increased. This suggests that vitamin D3 might play a role in modulating the inflammatory processes related to knee OA.
Ultimately, our findings highlight the potential of vitamin D3 supplementation as a promising therapeutic option for managing knee OA symptoms. Further research is warranted to delve deeper into the role of IL-33 and its implications for osteoarthritis.
Over the course of the study, we measured the participants' pain levels and functionality using WOMAC subscores and Visual Analog Scale (VAS) assessments. Excitingly, we found that the average pain intensity decreased significantly after treatment. In fact, about 87% of the participants showed a notable positive response to the vitamin D3 supplementation.
Alongside improvements in pain, we also noted changes in certain inflammation markers in the blood. There was a significant decrease in pro-inflammatory cytokines like TNF-α and IL-17, while levels of IL-33 increased. This suggests that vitamin D3 might play a role in modulating the inflammatory processes related to knee OA.
Ultimately, our findings highlight the potential of vitamin D3 supplementation as a promising therapeutic option for managing knee OA symptoms. Further research is warranted to delve deeper into the role of IL-33 and its implications for osteoarthritis.
Read More
Most Useful Reviews
8.8
Reduced toe pain
I've used this product for over 15 years and absolutely love it. I believe it has alleviated the pain in my big toe caused by osteoarthritis.
Read More
8.8
Less knee pain
As a previous sceptic, I researched Omega 3 and Nordic Naturals received high ratings. The product has genuinely exceeded my low expectations. I’ve noticed uplifting effects on my mood, and my knee pain has diminished. However, I still rely on prescription anti-inflammatories as I await knee replacement surgery. I recommended it to a friend with chronic depression, and her mood has improved significantly.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.2
9
Vitamin D3 reduces knee OA pain
The influence of vitamin D supplementation on the expression of mediators of inflammation in knee osteoarthritis.
High relevance to knee pain treatment
We aimed to understand the therapeutic impact of vitamin D3 on knee pain associated with osteoarthritis (OA). In a 3-month open-label clinical trial, we observed 80 patients with knee OA who took an oral supplement of vitamin D3 at a dosage of 4000 IU per day.
Over the course of the study, we measured the participants' pain levels and functionality using WOMAC subscores and Visual Analog Scale (VAS) assessments. Excitingly, we found that the average pain intensity decreased significantly after treatment. In fact, about 87% of the participants showed a notable positive response to the vitamin D3 supplementation.
Alongside improvements in pain, we also noted changes in certain inflammation markers in the blood. There was a significant decrease in pro-inflammatory cytokines like TNF-α and IL-17, while levels of IL-33 increased. This suggests that vitamin D3 might play a role in modulating the inflammatory processes related to knee OA.
Ultimately, our findings highlight the potential of vitamin D3 supplementation as a promising therapeutic option for managing knee OA symptoms. Further research is warranted to delve deeper into the role of IL-33 and its implications for osteoarthritis.
Over the course of the study, we measured the participants' pain levels and functionality using WOMAC subscores and Visual Analog Scale (VAS) assessments. Excitingly, we found that the average pain intensity decreased significantly after treatment. In fact, about 87% of the participants showed a notable positive response to the vitamin D3 supplementation.
Alongside improvements in pain, we also noted changes in certain inflammation markers in the blood. There was a significant decrease in pro-inflammatory cytokines like TNF-α and IL-17, while levels of IL-33 increased. This suggests that vitamin D3 might play a role in modulating the inflammatory processes related to knee OA.
Ultimately, our findings highlight the potential of vitamin D3 supplementation as a promising therapeutic option for managing knee OA symptoms. Further research is warranted to delve deeper into the role of IL-33 and its implications for osteoarthritis.
Read More
9
Vitamin D3 aids post-surgery recovery
Vitamin D Trajectory after Total Knee Arthroplasty: A Method for Quick Correction in Deficient Patients.
Study highly relevant to knee surgery
We explored the effects of vitamin D (D3) on knee pain recovery after total knee arthroplasty (TKA). In our study, we enrolled 60 patients and categorized them into three groups based on their vitamin D levels. Some patients had sufficient vitamin D, while others were either given large doses of oral or intramuscular supplementation if they were found to be insufficient.
Our findings revealed that patients with insufficient vitamin D experienced significant improvements in their knee function after receiving large oral doses. In fact, those who received oral supplements showed recovery comparable to patients who already had sufficient vitamin D. Conversely, while intramuscular supplementation did increase vitamin D levels, it was less effective compared to the oral method and only showed noticeable improvement by the two-week mark.
Interestingly, we also noted that about 25% of patients who initially had sufficient vitamin D levels became insufficient within the first two weeks post-surgery. This indicates that even those with adequate levels may need to consider supplementation after undergoing TKA to maintain optimal recovery.
In summary, our study suggests that quickly addressing vitamin D deficiency with oral supplementation can play a crucial role in enhancing recovery and reducing knee pain following TKA.
Our findings revealed that patients with insufficient vitamin D experienced significant improvements in their knee function after receiving large oral doses. In fact, those who received oral supplements showed recovery comparable to patients who already had sufficient vitamin D. Conversely, while intramuscular supplementation did increase vitamin D levels, it was less effective compared to the oral method and only showed noticeable improvement by the two-week mark.
Interestingly, we also noted that about 25% of patients who initially had sufficient vitamin D levels became insufficient within the first two weeks post-surgery. This indicates that even those with adequate levels may need to consider supplementation after undergoing TKA to maintain optimal recovery.
In summary, our study suggests that quickly addressing vitamin D deficiency with oral supplementation can play a crucial role in enhancing recovery and reducing knee pain following TKA.
Read More
9
Vitamin D3 alleviates knee pain
Restorative Effect of Vitamin D Deficiency on Knee Pain and Quadriceps Muscle Strength in Knee Osteoarthritis.
High relevance to knee pain treatment
We aimed to understand how vitamin D3 supplementation influences knee pain and muscle strength in individuals suffering from knee osteoarthritis (KOA). The study involved 67 patients over the age of 30, all experiencing knee pain for at least a month and showing signs of vitamin D deficiency.
Participants received a weekly dose of 50,000 IU of oral cholecalciferol (vitamin D3) for a span of two months. By the end of the treatment, nearly all participants had sufficient levels of vitamin D. Significant improvements were observed; serum vitamin D levels rose, quadriceps muscle strength increased, and knee pain decreased for the majority of participants.
Specifically, the pain reduction was measurable through standard pain assessment methods. The findings suggest a clear link between correcting vitamin D deficiency and improvements in both muscle strength and pain levels for those living with KOA.
Participants received a weekly dose of 50,000 IU of oral cholecalciferol (vitamin D3) for a span of two months. By the end of the treatment, nearly all participants had sufficient levels of vitamin D. Significant improvements were observed; serum vitamin D levels rose, quadriceps muscle strength increased, and knee pain decreased for the majority of participants.
Specifically, the pain reduction was measurable through standard pain assessment methods. The findings suggest a clear link between correcting vitamin D deficiency and improvements in both muscle strength and pain levels for those living with KOA.
Read More
9
Case study of knee pain relief
Adult Fanconi syndrome with proximal muscle weakness and hypophosphatemic osteomalacia: report of a case.
Mixed treatment benefits observed
We examined the impact of vitamin D3 in a patient suffering from adult Fanconi syndrome, who experienced notable knee pain among other symptoms. This individual, a 42-year-old female, presented with various issues including progressive proximal muscle weakness and marked bone discomfort, particularly in the knees. After a thorough evaluation that included electromyography and a muscle biopsy, she was diagnosed with this rare condition, which often results in deficiencies that can lead to significant pain and discomfort.
Following a comprehensive treatment plan, which included tricalcium phosphate, vitamin D3, and sodium bicarbonate, we observed positive changes in her symptoms. The patient's knee pain, along with other discomforts, notably improved after a six-week supplementation regimen. However, it's essential to clarify that while vitamin D3 was part of a combined treatment, the specific contribution of vitamin D3 to alleviating knee pain is hard to isolate. We conclude that vitamin D3 may offer some benefits when included in a broader treatment framework, but further research would be needed to fully understand its role in managing knee pain specifically.
Following a comprehensive treatment plan, which included tricalcium phosphate, vitamin D3, and sodium bicarbonate, we observed positive changes in her symptoms. The patient's knee pain, along with other discomforts, notably improved after a six-week supplementation regimen. However, it's essential to clarify that while vitamin D3 was part of a combined treatment, the specific contribution of vitamin D3 to alleviating knee pain is hard to isolate. We conclude that vitamin D3 may offer some benefits when included in a broader treatment framework, but further research would be needed to fully understand its role in managing knee pain specifically.
Read More
9
Eicosapentaenoic Acid Reduces Knee Pain
Efficacy of Extract and/or an Omega-3-Based Product for Improving Pain and Function in People Older Than 40 Years with Persistent Knee Pain: A Randomized Double-Blind Controlled Clinical Trial.
Study explores combined supplement effects
We conducted a study to investigate how eicosapentaenoic acid (EPA), a component of omega-3 fatty acids, impacts knee pain in healthy adults over the age of 40 with persistent discomfort. The study was structured as a randomized, double-blind, controlled clinical trial, which means that participants were assigned to either an EPA product or a placebo without knowing which they were receiving.
Over eight weeks, we observed four different groups: those taking pure EPA, those on a blend of EPA and another supplement, those on just the other supplement, and a placebo group. Our findings revealed that participants who consumed the EPA-based product experienced significant reductions in pain as measured by a visual analog scale (VAS), with the most noticeable improvements at the end of the eight weeks.
Additionally, the use of EPA seemed to enhance the quality of life by improving overall function and even aiding in better sleep quality. We also noted that the time taken to complete mobility tasks improved after the use of the EPA product. All participants reported safety, making EPA an appealing option for managing knee pain.
However, it’s important to note that the study included a combination of supplements, making it difficult to isolate the specific effects of just the eicosapentaenoic acid. Despite this, we feel confident in stating that incorporating EPA could be beneficial for those struggling with knee pain.
Over eight weeks, we observed four different groups: those taking pure EPA, those on a blend of EPA and another supplement, those on just the other supplement, and a placebo group. Our findings revealed that participants who consumed the EPA-based product experienced significant reductions in pain as measured by a visual analog scale (VAS), with the most noticeable improvements at the end of the eight weeks.
Additionally, the use of EPA seemed to enhance the quality of life by improving overall function and even aiding in better sleep quality. We also noted that the time taken to complete mobility tasks improved after the use of the EPA product. All participants reported safety, making EPA an appealing option for managing knee pain.
However, it’s important to note that the study included a combination of supplements, making it difficult to isolate the specific effects of just the eicosapentaenoic acid. Despite this, we feel confident in stating that incorporating EPA could be beneficial for those struggling with knee pain.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
8.8
Reduced toe pain
I've used this product for over 15 years and absolutely love it. I believe it has alleviated the pain in my big toe caused by osteoarthritis.
8.8
Less knee pain
As a previous sceptic, I researched Omega 3 and Nordic Naturals received high ratings. The product has genuinely exceeded my low expectations. I’ve noticed uplifting effects on my mood, and my knee pain has diminished. However, I still rely on prescription anti-inflammatories as I await knee replacement surgery. I recommended it to a friend with chronic depression, and her mood has improved significantly.
Read More
